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Volunteers needed for intra-dermal JE vaccine trial (JEVID)

October 1st, 2021

We need your help for a research project on Japanese Encephalitis Vaccine

In this study, we are using the normal, registered JE vaccine. This vaccine is already widely used in Australia and is very effective, but normally costs about $300 per dose. Unfortunately, many travellers who would otherwise like to be vaccinated are forced to decline due to the cost. In this research, we are investigating the effectiveness of giving a micro-dose of the vaccine into the top layer of the skin (intradermal, or I.D.) instead of giving a full dose into the muscle (as JE vaccine is normally given). Using a lower dose in this way makes the vaccine cheaper and less painful for the recipients, and is known to be a safe and effective method of giving other types of vaccines (such as rabies).

If you  are between 18 and 45 years of age, and think you might travel to Asia at some point in the future, this is a great opportunity to get the JE vaccine free of charge while also helping to make it more accessible to other travellers in the future.

If none of the following exclusion criteria apply to you, we would be very grateful if you would consider participating.

You will not be able to participate in this study if:

  • You live outside Brisbane (as the research is being done in Brisbane)
  • You have lived in a  JE risk area for 12 months or more
  • You have had dengue fever
  • You have previously had vaccines against  JE, yellow fever, or dengue, or are planning to have yellow fever or dengue vaccines during the next two months
  • You have contraindications to the Imojev vaccine or live vaccines – like being on immunosuppressive medication
  • You are pregnant or planning to get pregnant (If clinically relevant, a urine pregnancy test can be done at the clinic prior to enrolment)
  • You are breastfeeding
  • You have a disease or are on any medication that suppresses your immune system (e.g. cancer or chemotherapy)
  • You are travelling or planning to travel to areas of high risk for JE within the next two months

 

So what would we be asking you to do?

Have a blood test and get the microdose of the Australian-registered JE vaccine at our clinic in the city.

THEN Visit the clinic one month later for a blood test to check your response.

THEN Visit the clinic another month later for a final blood test to check your response after 2 months.

(Unfortunately for this project you cannot go to a regular pathology lab as the test for these antibodies is very specialised and being done by the QIMR Berghofer Research Institute  https://www.qimrberghofer.edu.au)

You will get your results at the end of the research.

 

There is of course no cost to you except for your time. Participants receive $50 on the 3rd visit to help allay your incidental costs such as parking etc.

 

The research is being conducted in association with the University of QLD and has full ethics approval.

More details on the research can be found here: https://www.thetraveldoctor.com.au/jevid/

Here is a link to our earlier research:  https://www.crestma.com.au/published-research/

Finally, it is only through the assistance of participants such as yourself that research is able to advance medical science, especially when it comes to vaccines.

 

We would be thrilled if you were in a position to help by participating in this research project. To enrol or ask for more information, simply call the clinic on 32219066 and ask to speak to the research staff, or reply to me at this email.

 

You can also make a booking online if that is convenient, at http://bit.ly/DrDebAppts. Just choose the appointment type  JEVID clinical research.

 

FURTHER INFO

Japanese encephalitis (JE) is a dangerous disease in Asia spread by mosquitoes

The full participant information sheet is here: JEVID participant information vs 5

If you would like more information, please call the clinic 0732219066 and ask to speak to Chris who is our research assistant or send us a message here.

Could you help? Do you know someone ?friends ?colleagues ?relatives who might be interested?  please tell them or share this page. Medical research relies on volunteers to help research better medical care.

Regardless of your availability for this project, my staff and I look forward to helping you travel sometime soon, when travel returns to normal.

For now, even though travel is currently paused, we are still working towards making it safer.

Dr Deb and the CRESTMA research team

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